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Image Search Results
Journal: PLoS ONE
Article Title: Centrally Administered Pertussis Toxin Inhibits Microglia Migration to the Spinal Cord and Prevents Dissemination of Disease in an EAE Mouse Model
doi: 10.1371/journal.pone.0012400
Figure Lengend Snippet: Normal +IgG: age-controlled normal mice without EAE receiving a single i.p. injection of rabbit IgG (100 µg/mouse). 7 days EAE: EAE mice on day 7 post immunization; no penetration of rabbit IgG observed in the brain or spinal cord. 14 days EAE: EAE mice on day 14; marked penetration of rabbit IgG noted in both brain and spinal cord. 7 days EAE +PTx: EAE +PTx icv mice on day 7 post immunization; marked penetration of the brain, but no penetration of the spinal cord. 14 days EAE +PTx: EAE +PTx icv mice on day 14 post immunization, continued evidence of brain penetration, no penetration of the spinal cord. Note the dramatic opening of the BBB on Days 7 in EAE +PTx icv group relative to EAE on day 7.
Article Snippet: Mice were injected intraperitoneally (i.p.) with 100 µg purified
Techniques: Injection